Life Science - Metabolics

Accurate determination of changes in molecular profile related to disease, disease progression, therapeutic intervention, genetic modification or environmental variation are the hallmarks of the field known as metabolomics.

 

Bruker provides all the “pieces” to solve the “metabolomics puzzle” with integrated and advanced technical solutions.

Metabolomic analysis must accurately determine even the slightest changes of molecular profile related to disease, disease progression, therapeutic intervention, genetic modification or environmental variation. Thanks to the latest innovations in hyphenated NMR, LC-MS, GC-MS and FT-IR technologies, Bruker remains the leader in integrated solutions for metabolomics.

Systems can be used for a broad variety of targeted and non-targeted metabolomics studies. They are very well equipped to detect, identify, and measure metabolome molecules covering the entire metabolomics chemical space. Bruker provides all hardware and software “puzzle pieces” to give a complete picture of the metabolome.

In metabolomics there is an increasing need for efficient data processing tools, and Bruker has strengthened its bioinformatics offering with Compass™ PathwayScreener software to provide a new layer of insight into metabolomics samples. With the new Compass PathwayScreener, users can get twice the results, performing pathway-driven, targeted metabolomics analysis on the same dataset used for non-targeted data mining. The PathwayScreener workflow can be integrated with Bruker’s market-leading multi-OMICS bioinformatics platform ProfileAnalysis™ for non-targeted metabolomics and label free proteomics studies.

“UsingCompass PathwayScreener we were able to elucidate novel influences of mutants on metabolic networks in Corynebacterium glutamicum.” -Professor Jörn Kalinowski, at the Center for Biotechnology in Bielefeld, Germany,

 “As a co-PI of the Human Metabolome Database (HMDB) project, my laboratory generated the original MS/MS spectral library of about 800 human metabolites using low-resolution triple quadrupole mass spectrometry. We are delighted to collaborate with Bruker to produce a new Human Metabolite MS/MS spectral library with much improved spectral quality. This library, along with an automated acquisition and processing strategy, allows users to identify metabolites very quickly with high confidence.”  Professor Liang Li, University of Alberta  


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